What to Expect in Your First Week on GLP-1 Medications

Starting GLP-1 medications can be an exciting step toward better health, whether you’re using them for diabetes management or weight loss. However, the first week can bring its own set of experiences, including potential side effects and adjustments. Understanding what to expect can help you prepare and maximise the benefits of your treatment.

Potential Side Effects

It’s common to experience side effects in the first week as your body adjusts to the medication. The most frequently reported side effects include:

1. Nausea: This is the most common side effect and can range from mild to severe.

2. Vomiting: Some people may experience this, especially if they eat large meals or fatty foods.

3. Constipation or Diarrhoea: Digestive system adjustments can cause changes in bowel habits.

4. Fatigue: A feeling of tiredness as your body adapts to appetite suppression and other effects.

These side effects are typically temporary and can often be managed by starting with a low dose and gradually increasing it under the guidance of your healthcare provider.

Why Start with a Low Dose?

GLP-1 medications are usually started at a low dose to minimise side effects and allow your body to adapt. Your healthcare provider will gradually increase the dosage over weeks or months based on your response. Skipping this step or starting with a higher dose can increase the risk of severe side effects, including nausea and vomiting.

Dietary Adjustments

The medication’s effect on appetite and digestion means your eating habits may need some tweaks to ensure comfort and effectiveness. Here are some dietary tips:

1. Focus on Fibre

GLP-1 medications slow gastric emptying, which can lead to constipation. Eating enough fibre is crucial for maintaining healthy digestion. Aim for at least 30 grams of fibre daily from sources like:

• Vegetables: Broccoli, carrots, leafy greens

• Fruits: Apples, pears, berries

• Whole grains: Oats, quinoa, brown rice

• Legumes: Lentils, chickpeas, black beans

2. Stay Hydrated

Adequate water intake is essential to combat slow transit times in your digestive tract. Aim for at least 8-10 glasses of water daily and consider drinking herbal teas if plain water becomes monotonous.

3. Smaller, Balanced Meals

Large meals can exacerbate side effects like nausea. Opt for smaller, balanced meals that include:

• Protein: Chicken, fish, eggs, tofu

• Healthy carbs: Sweet potatoes, whole-grain bread, brown rice

• Fibre-rich vegetables: Spinach, Brussels sprouts

Avoid high-fat and overly processed foods, as they can worsen gastrointestinal symptoms and increase the risk of gallstones.

Lifestyle Tips for Your First Week

1. Take ‘Before’ Pictures

Documenting your starting point can be a powerful motivator. Take photos, measurements and note how you feel physically and emotionally. These records will help you track your progress and celebrate milestones.

2. Eat Mindfully

GLP-1 medications reduce appetite, but it’s important to ensure you’re eating enough to meet your nutritional needs. Pay attention to hunger cues and avoid skipping meals.

3. Plan for Rest

Fatigue is a common side effect in the first week. Give yourself permission to rest and prioritise sleep to help your body adjust.

4. Stay Active

While intense workouts might not be ideal during your first week, light activities like walking or stretching can improve digestion and energy levels.

When to Call Your Healthcare Provider

While mild side effects are normal, certain symptoms warrant immediate attention:

• Severe nausea or vomiting that prevents you from keeping food or liquids down

• Persistent abdominal pain, which could indicate gallstones or other complications

• Signs of dehydration, such as dark urine or dizziness

Don’t hesitate to reach out to your healthcare provider with any concerns or questions.

The first week on GLP-1 medications can come with adjustments, but being prepared can make the transition smoother. Focus on managing potential side effects, maintaining a balanced diet, and staying hydrated. Small steps, like taking before pictures and adopting mindful eating habits, will set you up for success on your health journey. Remember, your healthcare provider is there to support you every step of the way.